Ketamine has been found to be effective for patients who have not responded to other medications or therapies, making it a valuable option for those who have exhausted other options. It has a unique ability to rapidly reduce symptoms of suicidal ideation, which is particularly important for patients who are at risk of self-harm.

The mechanism of action for ketamine’s behavioral effects is not fully understood, but it is thought that by binding to N-Methyl-D-Aspartate (NMDA) receptors, ketamine appears to increase the amount of a neurotransmitter called glutamate in the spaces between neurons. Glutamate then activates connections in another receptor, called AMPA receptor. Together, the initial blockade of NMDA receptors and activation of AMPA receptors lead to release of other molecules that help neurons communicate with each other along new pathways process known as synaptogenesis. This process likely affects mood, thought patterns, and cognition.

For neuropathic pain and complex regional pain syndrome (CRPS), hyper-regulation and central sensitization are triggered by stimulation NMDA receptors and appears to be the primary neurological processes. Ketamine changes this central pain-processing. In lay language it is like pressing the reset button to restore the normal pain processing.

Overall, while ketamine infusion therapy shows promise as a treatment option for behavioral health problems and chronic pain conditions, it should be considered only as an adjunct to other evidence-based treatments and under the care of healthcare professionals. Do not let these behavioral health problems control your life any longer – talk to your healthcare professional about the possibility of ketamine infusion therapy and take the first step towards a brighter future.

What is Ketamine?

Ketamine is a medication that has been recognized for its anesthetic properties for over 50 years. It is commonly used by ER physicians and anesthesiologists during procedures and surgeries. Recently, ketamine infusion has shown effectiveness in treating depression, anxiety, PTSD, and certain pain syndromes. Ketamine is approved by the FDA as a sedative and is listed as an essential medicine by the World Health Organization.

Is ketamine safe?

Ketamine is a very safe drug. As anesthesiologists, we regularly administer this drug at much higher dosages in operating rooms.

What does ketamine do to the brain?

Ketamine acts on the brain in various ways. It promotes physical growth in the prefrontal cortex, establishing new connections between neurons. Ketamine also increases the activity of NMDA receptor neurotransmitters like glutamate, which helps create new pathways in the brain, leading to improvements in mood, sleep, and other areas of function.

Are there any concerning side effects?

It is common for patients to feel tired after the infusion. Some patients may experience mild nausea, which can be treated with anti-nausea medications. Other possible side effects include temporary changes in blood pressure, heart rate, coordination, and dissociation. Rarely, more serious effects such as hallucinations or increased intracranial pressure may occur. However, side effects are typically short-lived and last only a few hours.

What is Spravato (Esketamine) and how is it different from IV Ketamine infusion?

Spravato, also known as Esketamine, is a nasal spray formulation of ketamine. It contains the S-enantiomer of ketamine, whereas traditional ketamine infusion includes both the S and R enantiomers. Spravato has received FDA approval for treating treatment-resistant depression. The main differences from IV ketamine infusion lie in the method of administration and dosage.

How does ketamine infusion affect bipolar patients?

Ketamine infusion can have different effects on individuals with bipolar disorder. Bipolar patients need careful evaluation, and the infusion should be administered under the guidance of a qualified healthcare professional, as it can potentially trigger manic or hypomanic episodes.

General

Can i continue my daily Medications?

Normally patients continue their daily medications. However, physicians will evaluate medications during your initial consultation

Concerns

Which medical conditions is ketamine infusion not recommended for?

Ketamine infusion is generally not recommended for individuals with uncontrolled high blood pressure, acute or unstable cardiovascular disease, uncontrolled thyroid disease, elevated intracranial pressure, history of psychosis, manic phase of bipolar disorder, uncontrolled glaucoma, current pregnancy, or prior adverse effects from ketamine.

Is ketamine infusion age-specific?

Ketamine infusion can be administered to individuals across different age groups. However, its suitability and dosage may vary based on factors such as medical history, overall health, and the specific condition being treated. A consultation with a healthcare professional is essential to determine if ketamine infusion is appropriate for you.

Before Infusion

What should I do on the day of my ketamine infusion?

On the day of your ketamine infusion, it is important to follow any specific instructions given by your healthcare provider. Please do not eat or drink anything for at least 6 HOURS prior to your infusion. Arrive on time and be prepared to stay for the designated duration of the infusion. You must have an ESCORT to drive you home. THIS IS NON-NEGOTIABLE. Wear loose- fitting, comfortable clothing.

Can I take my regular medications on the day of the infusion?

In most cases, you can take your regular medications as prescribed on the day of the infusion. However, it is crucial to inform your healthcare provider about all the medications you are currently taking to ensure there are no potential interactions with ketamine or other administered drugs.

During Infusion

What happens during a ketamine infusion session?

During a ketamine infusion session, you will be comfortably seated or lying down in a calm and supervised environment. Our anesthesiologist will administer the ketamine through an intravenous (IV) line. Vital signs such as blood pressure, heart rate, and oxygen levels will be monitored throughout and after the infusion by an ACLS certified healthcare provider.

Will I be awake during the ketamine infusion?

Yes, you will typically be awake and conscious throughout the ketamine infusion. However, it is common to experience a dissociative state and altered perception during the treatment. You may also feel deeply relaxed or experience other subjective effects.

How long does a ketamine infusion session last?

The duration of a ketamine infusion session for depression patients can vary, but it usually lasts 40 to 45 minutes, with additional 20 to 30 minutes of recovery time. The exact length depends on factors such as the dosage, treatment protocol, and individual response to the infusion.

Treatment efficacy/ Durability of effects

How soon can I expect to notice the effects of Ketamine infusion therapy?

The effects of ketamine infusion therapy can vary from person to person, and results cannot be guaranteed. However, more than 70% of patients with treatment-resistant mood disorders can expect significant relief with ketamine infusion. While some individuals may experience
immediate improvements in their symptoms, others may require several sessions before noticing significant changes. It is important to have realistic expectations and discuss your progress with your healthcare provider.

Will I need ongoing ketamine infusions for the rest of my life?

The need for ongoing ketamine infusions depends on your individual response and the specific condition being treated. Some individuals may require periodic maintenance infusions to sustain the benefits, while others may achieve long-lasting effects with a defined treatment course. Your healthcare provider will assess and discuss the appropriate treatment plan for you.

Legal & Compliance

Is ketamine infusion therapy legal?

Yes, ketamine infusion therapy is legal when administered by qualified healthcare professionals and for approved medical purposes. It is important to seek treatment from licensed and authorized providers.

Is ketamine infusion FDA-approved?

While ketamine itself is FDA-approved as an anesthetic, the specific use of ketamine infusion for certain mental health conditions such as treatment-resistant depression is considered an off-label use. However, Esketamine (Spravato), which is a variant of ketamine, has received FDA approval for the treatment of treatment-resistant depression under specific protocols and guidelines.

Is your ketamine infusion clinic compliant with all the legal regulations?

Yes, our ketamine infusion clinic strictly adheres to all applicable legal regulations and requirements. We prioritize patient safety and ensure that our services are provided within the scope of the law.

Are your healthcare professionals properly licensed and trained?

Absolutely. Our healthcare professionals are highly qualified, licensed, and experienced in administering ketamine infusion therapy. They undergo specialized training to provide safe and effective treatment to our patients.

What steps do you take to ensure patient safety during ketamine infusion therapy?

Patient safety is our top priority. We maintain rigorous safety protocols and closely monitor patients throughout the entire ketamine infusion process. Our healthcare professionals are trained to handle any potential side effects or adverse reactions.

How do you ensure the quality and purity of the ketamine used in the infusions?

We source our ketamine from reputable suppliers and ensure that it meets the highest standards of quality and purity. Our ketamine is obtained from reliable pharmaceutical manufacturers and undergoes strict quality control measures.

Can you provide information about the clinical studies or research supporting ketamine infusion therapy?

We stay updated on the latest research and clinical studies related to ketamine infusion therapy. Our healthcare professionals can provide information and discuss the scientific evidence supporting the use of ketamine infusion for specific conditions.

After Infusion

What can I expect after the ketamine infusion?

After the infusion, you may continue to feel the effects of ketamine, and you may feel drowsy or disoriented for a period of time. It is important to have someone escort you home and refrain from driving or operating heavy machinery for at least 24 hours following the infusion.

Are there any specific instructions for the day following the ketamine infusion?

There are specific instructions for the post-infusion period. These include avoiding certain activities such as driving or using any heavy equipment, abstaining from alcohol use or sedatives, not making any important decisions for up to 24 hours following the infusion, and resuming your regular medications as directed.

IV ketamine infusion vs Spravato?

Ketamine infusion is administered intravenously, while Spravato (Esketamine) is administered intranasally. To understand the pros and cons of each treatment option, we recommend scheduling a free consultation.

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