Ketamine has been found to be effective for patients who have not responded to other medications or therapies, making it a valuable option for those who have exhausted other options. It has a unique ability to rapidly reduce symptoms of suicidal ideation, which is particularly important for patients who are at risk of self-harm.

The mechanism of action for ketamine’s behavioral effects is not fully understood, but it is thought that by binding to N-Methyl-D-Aspartate (NMDA) receptors, ketamine appears to increase the amount of a neurotransmitter called glutamate in the spaces between neurons. Glutamate then activates connections in another receptor, called AMPA receptor. Together, the initial blockade of NMDA receptors and activation of AMPA receptors lead to release of other molecules that help neurons communicate with each other along new pathways process known as synaptogenesis. This process likely affects mood, thought patterns, and cognition.

For neuropathic pain and complex regional pain syndrome (CRPS), hyper-regulation and central sensitization are triggered by stimulation NMDA receptors and appears to be the primary neurological processes. Ketamine changes this central pain-processing. In lay language it is like pressing the reset button to restore the normal pain processing.

Overall, while ketamine infusion therapy shows promise as a treatment option for behavioral health problems and chronic pain conditions, it should be considered only as an adjunct to other evidence-based treatments and under the care of healthcare professionals. Do not let these behavioral health problems control your life any longer – talk to your healthcare professional about the possibility of ketamine infusion therapy and take the first step towards a brighter future.